November 2019 – Although plasma EBV DNA measurement has established prognostic utility in EBV‐driven lymphomas, findings from this study suggest that EBV reactivation in nontumor cells is a poor prognostic finding even in HIV‐positive patients with convincingly EBV‐negative DLBCL.
June 2019 – This article highlights the important role of cancer care and research outside the United States, particularly in low- and middle-income countries, in furthering innovative solutions for cancer that can be applied worldwide.
April 2019 – Studies on malignant melanoma have largely focused on Caucasian populations with very limited data on the disease in black Africans. This retrospective study characterizes melanoma cases in Lilongwe, Malawi and demonstrates that malignant melanoma occurs in black … Continued
December 2018- Outcomes for diffuse large B-cell lymphoma (DLBCL) in sub-Saharan Africa are poorly described. We report mature data from one of the first prospective SSA cohorts and propose a setting-appropriate prognostic model.
December 2018- In sub-Saharan Africa, limited epidemiological data describe cancer burden among ART users. We link cases from the population-based cancer registry with EMRs supporting ART delivery in Malawi’s two largest HIV cohorts, Lighthouse Trust and Queen Elizabeth Central Hospital to … Continued
November 2018- Despite high burden of Kaposi sarcoma and HIV, multicentric Castleman disease is rarely reported in SSA. To supplement previous reports on MCD cases in Malawi, we describe a larger cohort of MCD patients with longer follow-up.
September 2018- Although HIV and HHV8 are highly prevalent in SSA, there are scarce reports of primary effusion lymphoma (PEL) from the region, likely reflecting underdiagnosis. This article describes the two recently confirmed cases of extracavitary PEL in Malawi.
July 2018- Although highly effective, high-intensity cytotoxic treatments for Burkitt lymphoma are available in resource-rich settings, these therapies are usually not feasible in SSA, and lower-intensity continuous infusion approaches are impractical. We review current treatment approaches in SSA and discuss … Continued
June 2018- Despite high prevalence of HIV in SSA, descriptions of Plasmablastic lymphoma (PBL) are scare. In one of the first clinical descriptions of PBL, we report on characteristics, treatment, and outcomes of 12 pathologically confirmed PBL cases in Lilongwe.
June 2018- Efforts to translate and culturally validate patient-reported health-related quality of life measures are scarce in SSA are scarce. This study translates the PROMIS-25 to Chichewa and assesses its validity and reliability in our setting.
June 2018- We report the epidemiology of patients with cancer recorded by a de novo hospital-based cancer registry at Kamuzu Central Hospital, the sole provider of comprehensive oncology services for half the country and location of a high-volume pathology laboratory.
April 2018- Cancer care in resource-limited settings is radically different from cancer care in resource-rich settings. Drs. Painschab and Gopal comment on the urgent need for region-specific data and clinical trials to address the rising cancer burden in SSA.
March 2018 – The care of patients with lymphoma relies heavily on accurate tissue diagnosis and classification. Lymphoma burden is increasing in sub-Saharan Africa, but diagnostic pathology services are still limited. This article summarizes lymphoma epidemiology, current diagnostic capacity, and obstacles and opportunities for improving practice in the region.
October 2017- In this essay, Dr. Satish Gopal addresses why he provides cancer care and conducts research in Malawi, and how global health efforts benefit the United States and human health more broadly.
September 2017- Our experience with these patients highlights that ENKTCL does indeed occur in SSA, increases familiarity with ENKTCL among clinicians and pathologists throughout the region, and emphasizes the need for better diagnosis and treatment for this neglected population.
August 2017 – Lymphoma is highly associated with HIV in sub-Saharan Africa and contributes to worse outcomes relative to resource-rich settings. This study describes 21 patients with relapse or refractory lymphoma who were prospectively treated with salvage chemotherapy in Malawi.
June 2017 – An international workshop aimed at examining the state of current science regarding esophageal squamous cell carcinoma. These discussions highlight a series of difficult questions which are recommended to inform and prioritize future research efforts.
April, 2017 – Breast cancer is very common in Sub-Sahara Africa, but many misconceptions about it make early detections and treatment difficult. This study looks at what misconceptions exist and what barriers need to be addressed.
March 2017 – Diagnosing pediatric Burkitt Lymphoma in sub-Saharan Africa is difficult, as many tools are currently not available. This study found that measuring Epstein-Barr virus DNA could help with setting the diagnosis, prognosis, and predicting the response.
February 2017 – A 26-year-old woman in Malawi presented with classical Hodgkin lymphoma, while she was pregnant. This case report describes the treatment that cured her and allowed for the delivery of a healthy daughter.
January 2017 – Clinical breast exams can be a valuable tool in early detection of breast cancer. This study explores the effects of a breast cancer educational talk and breast cancer screenings among women attending urban health clinics in Malawi.
January 2017- Kaposi’s sarcoma (KS) is the leading cancer in much of sub-Saharan Africa. HIV has resulted in a dramatic increase in KS throughout the region, due to high overlapping prevalence of HIV and the etiologic agent of KS, Kaposi’s sarcoma-associated … Continued
January 2017 – Many women in sub-Saharan Africa are diagnosed with advanced-stage breast cancer. This study explores Malawian breast cancer patients’ perspectives regarding their diagnosis and ability to access care.
January, 2017 – This review highlights recent developments for HIV-associated malignancies in low and middle income countries and suggests that sustained investment within these settings can help catalyze a cancer care and research agenda that benefit patients worldwide.
November 2016 – Limited follow-up with incomplete retention is common among studies involving pediatric lymphoma patients in sub-Saharan Africa. This study examines the effects of retention and follow-up times on overall survival estimates.
October 2016 – Classical Hodgkin lymphoma (cHL) is a common malignancy among children and young adults. However, there are no prospective clinical studies of cHL from SSA from recent years, when ART is widely available.
October 2016- This study demonstrates discrete subtypes of esophageal squamous cell carcinoma (ESCC) in SSA, and suggests that the endemic nature of this disease reflects exposure to a carcinogen other than tobacco and oncogenic viruses.
September 2016 – Results of a two-year collaboration between Kamuzu Central Hospital and the University of North Carolina to establish a pathology laboratory in Lilongwe, Malawi, showing high concordance between real-time diagnoses in Malawi and final diagnoses in the US.
July 2016 – To make early detection of breast cancer in Malawi possible, training laywomen to screen seems to be a viable option. 1000 examinations provide the evidence that the quality of these screening compares to screenings performed by clinicians.
June 2016 – This paper describes a paediatric cohort of patients with Burkitt lymphoma, the most prevalent paediatric cancer in Malawi. Using the more intense CHOP-regimen to treat those patients did not improve the outcome significantly.
April 2016 – This opinion piece describes the disparities between cancer prevention and treatment in Malawi versus in the developed world, and questions the ethics of funding health care through academic grants.
March 2016 – Description of a clinical breast exam training program administered to laywomen in Malawi. Participants who completed training demonstrated competency in conducting clinical breast exams and delivering breast cancer educational talks.
March 2016 – With no previous prospective studies of aggressive non-Hodgkin lymphoma treated with CHOP in sub-Saharan Africa, results of this study suggest that CHOP can be safe, effective, and feasible for treating aggressive NHL among HIV+/- individuals in Malawi.
December 2015 – Representing the first published comparison of bone marrow eosinophil density between patients from SSA and a developed nation, this study shows an increased density among patients in Malawi compared to patients in the US.
December 2015 – Breast cancer screening with mammography for early detection of breast cancer is recommended in high-income countries, but in low- and middle income countries the risk/benefit ratio might be different.